Numerical Simulation of Organ on Chip Systems

Mehrdel, Pouya | 2015

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  1. Type of Document: M.Sc. Thesis
  2. Language: English
  3. Document No: 46997 (58)
  4. University: Sharif University of Technology
  5. Department: Science and Engineering
  6. Advisor(s): Saeedi, Mohammad Saeed; Sani, Mehdi
  7. Abstract:
  8. Discovering new medicines and generally medical researches, are time consuming and expensive. But recent achievements in cell culturing methods and micro and nano-engineering techniques have enabled the researchers to investigate new medicines in a lesser time and price. Huh et al. successfully fabricated the lung on chip device. This device is consisted of three chambers. The middle chamber is separated in two equal parts and side chambers were considered in order to apply normal breathing. Periodic deformation was needed to apply the natural condition of cultured cells by expansion and contraction. Numerical simulation was needed to investigate the properties of flow in this kind of devices. In the present research, results showed that for velocities higher than 0.1 mm/s in blood chamber, the shear stress would be enough to damage the endothelial cells. On the other hand, due to lower density of air, epithelial cells are not sensitive to air velocity. Moreover, a User Defined Function (UDF) was needed to apply periodic deformation to simulate the desired movement of the model. Applying this UDF model, showed that in low values of inlet velocity the flow streams move slower. However by increasing the initial velocity the relation between flow velocity and deformation decreased and by releasing particles inside air chamber this idea was confirmed. If the air velocity is equal to 1 mm/s, there will be a 20% of difference between the estimations of 2D model (for simplifying and reducing the required calculation time) and 3D model. But if the velocity is assumed 1 cm/s, the difference between the predictions of 2D model and 3D model decreases to 3%
  9. Keywords:
  10. Numerical Simulation ; Particles Tracking ; Organ on Chip ; Lab-on-a-Chip

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