Preparation and evaluation of bioactive and compatible starch based superabsorbent for oral drug delivery systems

Pourjavadi, A ; Sharif University of Technology | 2013

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  1. Type of Document: Article
  2. DOI: 10.1016/S1773-2247(13)50074-8
  3. Publisher: 2013
  4. Abstract:
  5. Novel types of highly swelling hydrogels (superabsorbent) were prepared by grafting crosslinked poly acrylic acid-co-2-hydroxyethylmetacrylate (PAA-co-HEMA) chains onto starch through a free radical polymerization method. The effect of grafting variables (i.e., concentration of methylenebisacrylamide (MBA), acrylic acid/2-hydroxy methymetacrylate (AA/HEMA) weight ratio, ammonium persulfate (APS), starch, neutralization percent, were systematically optimized to achieve a hydrogel with a maximum swelling capacity. The superabsorbent (SAP) formation was confirmed by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The controlled-release behavior of diclofenac sodium (DS) from SAP was investigated and showed that the release profiles of DS from superabsorbent polymer were slow (less than 6%) in simulated gastric fluid (SGF, pH 1.6) over 3 h, but nearly all of the initial drug content was released in simulated intestinal fluid (SIF, pH 7.4) within 8 h after changing media. Overall, the results demonstrated that biodegradable superabsorbent could successfully deliver a drug to the intestine without losing the drug in the stomach, and could be potential candidates for an orally administrated drug delivery system
  6. Keywords:
  7. 2-hydroxyethylmetacrylate ; Acrylic acid ; Diclofenac sodium ; Drug delivery system ; Hydrogel ; Cross linking reagent ; Diclofenac ; Free radical ; Poly acrylic acid co 2 hydroxyethylmetacrylate ; Polymer ; Starch ; Unclassified drug ; Animal cell ; Animal cell culture ; Animal experiment ; Controlled release formulation ; Drug design ; Drug formulation ; Drug synthesis ; Evaluation ; Fibroblast ; In vitro study ; Infrared spectroscopy ; Intestine fluid ; Mouse ; Nonhuman ; Polymerization ; Scanning electron microscopy ; Stomach juice ; Superabsorbent
  8. Source: Journal of Drug Delivery Science and Technology ; Volume 23, Issue 5 , 2013 , Pages 511-517 ; 17732247 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S1773224713500748