A meta-model analysis of a finite element simulation for defining poroelastic properties of intervertebral discs

Nikkhoo, M ; Sharif University of Technology | 2013

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  1. Type of Document: Article
  2. DOI: 10.1177/0954411913480668
  3. Publisher: 2013
  4. Abstract:
  5. Finite element analysis is an effective tool to evaluate the material properties of living tissue. For an interactive optimization procedure, the finite element analysis usually needs many simulations to reach a reasonable solution. The metamodel analysis of finite element simulation can be used to reduce the computation of a structure with complex geometry or a material with composite constitutive equations. The intervertebral disc is a complex, heterogeneous, and hydrated porous structure. A poroelastic finite element model can be used to observe the fluid transferring, pressure deviation, and other properties within the disc. Defining reasonable poroelastic material properties of the anulus fibrosus and nucleus pulposus is critical for the quality of the simulation. We developed a material property updating protocol, which is basically a fitting algorithm consisted of finite element simulations and a quadratic response surface regression. This protocol was used to find the material properties, such as the hydraulic permeability, elastic modulus, and Poisson's ratio, of intact and degenerated porcine discs. The results showed that the in vitro disc experimental deformations were well fitted with limited finite element simulations and a quadratic response surface regression. The comparison of material properties of intact and degenerated discs showed that the hydraulic permeability significantly decreased but Poisson's ratio significantly increased for the degenerated discs. This study shows that the developed protocol is efficient and effective in defining material properties of a complex structure such as the intervertebral disc
  6. Keywords:
  7. Finite element modeling ; Intervertebral disc ; Response surface methodology ; Finite element simulations ; Interactive optimization ; Poroelastic finite elements ; Comparison of materials ; Experimental deformation ; Poisson ratio ; Surface properties ; Telemetering ; Thermal barrier coatings ; Constitutive equations ; Implants (surgical) ; Animal ; Biological model ; Body fluid ; Computer simulation ; Human ; In vitro study ; Mechanical stress ; Metabolism ; Young modulus ; Poroelastic properties ; Response surface method ; In Vitro Techniques ; Stress, Mechanical ; ِِِِDegeneration model ; Animals ; Body Fluids ; Compressive Strength ; Elastic Modulus ; Humans ; Intervertebral Disc Degeneration ; Models, Biological ; Permeability ; Porosity ; Swine ; Tensile Strength ; Weight-Bearing ; Intervertebral disk
  8. Source: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 227, Issue 6 , 2013 , Pages 672-682 ; 09544119 (ISSN)
  9. URL: http://pih.sagepub.com/content/227/6/672