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Synthesis of 1,4-disubstituted 1,2,3-triazoles from aromatic α-bromoketones, sodium azide and terminal acetylenes via Cu/Cu(OTf)2-catalyzed click reaction under microwave irradiation

Fazeli, A ; Sharif University of Technology | 2013

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  1. Type of Document: Article
  2. DOI: 10.5560/znb.2013-3043
  3. Publisher: 2013
  4. Abstract:
  5. Reaction of aromatic α-bromoketones, sodium azide and aromatic or aliphatic terminal acetylenes in the presence of Cu/Cu(OTf)2following the classical method (aqueous acetonitrile at room temperature) and under microwave irradiation (H2O at 85 °C) leads to 1,4-disubstituted 1,2,3-triazoles as the final products after simple filtration
  6. Keywords:
  7. A-bromoketones ; 1,4-disubstituted 1,2,3-triazoles ; Click reaction ; Copper/copper triflate ; Cycloaddition ; Microwave irradiation ; Three-component reaction
  8. Source: Zeitschrift fur Naturforschung - Section C Journal of Biosciences ; Volume 68, Issue 4 , Apr , 2013 , Pages 391-396 ; 09395075 (ISSN)
  9. URL: http://www.degruyter.com/dg/viewarticle/j$002fznb.2013.68.issue-4$002fznb.2013-3043$002fznb.2013-3043.xml