Physiological temperature has a crucial role in amyloid beta in the absence and presence of hydrophobic and hydrophilic nanoparticles

Ghavami, M ; Sharif University of Technology | 2013

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  1. Type of Document: Article
  2. DOI: 10.1021/cn300205g
  3. Publisher: 2013
  4. Abstract:
  5. Amyloid beta fibrillation can lead to major disorder of neurons processes and is associated with several neuronal diseases (e.g., Alzheimer's disease). We report here an importance of slight temperature changes, in the physiological range (35-42 °C), on the amyloid fibrillation process in the presence and absence of hydrophilic (silica) and hydrophobic (polystyrene) nanoparticles (NPs). The results highlight the fact that slight increases in temperature can induce inhibitory and acceleratory effects of hydrophobic and hydrophilic NPs on the fibrillation process, respectively. Using further in vivo considerations, the outcomes of this study can be used for considerable modifications on the current diagnosis and treatment approaches in amyloid-involved diseases
  6. Keywords:
  7. Amyloid beta ; Fibrillation ; Hydrophilic NPs ; Hydrophobic NPs ; Physiological temperature ; Amyloid beta protein ; Nanoparticle ; Polystyrene ; Silicon dioxide ; Acceleration ; Body temperature ; Drug inhibition ; Human ; In vivo study ; Priority journal ; Amyloid beta-Peptides ; Hydrophobic and Hydrophilic Interactions ; Nanoparticles ; Physiological Phenomena ; Polystyrenes ; Temperature
  8. Source: ACS Chemical Neuroscience ; Volume 4, Issue 3 , December , 2013 , Pages 375-378 ; 19487193 (ISSN)
  9. URL: http://pubs.acs.org/doi/abs/10.1021/cn300205g