PLA microspheres-embedded pva hydrogels prepared by gamma-irradiation and freeze-thaw methods as drug release carriers

Behnoodfar, D ; Sharif University of Technology | 2013

976 Viewed
  1. Type of Document: Article
  2. DOI: 10.1080/00914037.2011.641648
  3. Publisher: 2013
  4. Abstract:
  5. A drug delivery system based on poly (vinyl alcohol) (PVA) hydrogels containing ibuprofen-loaded poly (lactic acid) (PLA) microspheres was developed to improve the release kinetics of this model drug. Gamma-irradiation and freeze-thawing were applied to prepare poly (vinyl alcohol) hydrogels. Properties and morphology of these composite hydrogels were investigated using FTIR, DSC, and SEM. In vitro release indicated that entrapment of the microspheres into the PVA hydrogels causes a reduction in both the release rate and the initial burst effect. PLA microspheres entrapped into the PVA hydrogels showed more suitable controlled release kinetics for drug delivery
  6. Keywords:
  7. PLA microspheres ; Composite hydrogels ; Controlled release ; Drug delivery system ; Drug release ; Freeze-thaw ; Freeze-thawing ; FTIR ; Gamma irradiation ; In-vitro ; Model drugs ; Poly(vinyl alcohol) (PVA) ; Polylactic acids ; PVA hydrogel ; Release kinetics ; Release rate ; Drug delivery ; Drug products ; Freezing ; Lactic acid ; Microspheres ; Hydrogels
  8. Source: International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 62, Issue 1 , 2013 , Pages 28-33 ; 00914037 (ISSN)
  9. URL: http://www.tandfonline.com/doi/abs/10.1080/00914037.2011.641648