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Monodispersed polymeric nanoparticles fabrication by electrospray atomization

Zarrabi, A ; Sharif University of Technology | 2012

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  1. Type of Document: Article
  2. DOI: 10.1080/00914037.2011.610048
  3. Publisher: 2012
  4. Abstract:
  5. The feasibility of fabricating relatively monodispersed polymeric nanoparticles by the electrospray method in a modified electrospray set-up is demonstrated in this study. The polymer solution is electrosprayed in the single cone-jet regime through a nozzle. After solvent evaporation, during which particles pave from the nozzle to collector, the fabricated nanoparticles can be collected in deionized water, which plays the role of surfactant for particles, not allowing them to aggregate. The results of scanning electron microscope and dynamic light scattering analysis clearly confirm the fabrication of monodispersed spherical polymeric nanoparticles with diameter range from 80 to 120nm with smooth surface
  6. Keywords:
  7. Drug delivery systems ; Electrospray ; PEG ; Electrospray method ; Electrosprays ; Mono-dispersed ; PLGA ; Polymeric nanoparticles ; Scanning Electron Microscope ; Smooth surface ; Solvent evaporation ; Agglomeration ; Deionized water ; Drug delivery ; Fabrication ; Nozzles ; Polyethylene glycols ; Scanning electron microscopy ; Surface active agents ; Nanoparticles
  8. Source: International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 61, Issue 8 , 2012 , Pages 611-626 ; 00914037 (ISSN)
  9. URL: http://www.tandfonline.com/doi/abs/10.1080/00914037.2011.610048