Loading...

Solubilities of acetaminophen in supercritical carbon dioxide with and without menthol cosolvent: Measurement and correlation

Karimi Sabet, J ; Sharif University of Technology | 2012

1080 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.scient.2011.11.046
  3. Publisher: 2012
  4. Abstract:
  5. The solubility of acetaminophen in SuperCritical-Carbon Dioxide (SC- CO 2) with and without menthol as a cosolvent was measured at various temperatures (313, 328 and 343) K, and within pressures ranging from (10 to 25) MPa. It should be stated that the cosolvent, menthol, has chiral isomers with different melting points. Therefore, the effects of both menthol (I) with a lower melting point and menthol (II) with a higher melting point, as cosolvents on the solubility of acetaminophen in SC- CO 2, were studied. The experimental data collected in this work were obtained using a static flow apparatus. The experiments were replicated at least three times and the data reported are the average of the replicas. Finally, the data reduction for the solubility of acetaminophen in SC- CO 2 in the presence and in the absence of menthol (I) and menthol (II), were correlated, using the semi-empirical equations proposed by Chrastil and Mendez-Santiago & Teja. The results obtained from these equations were in good agreement with the experimental data
  6. Keywords:
  7. Acetaminophen solubilities ; Menthol cosolvent ; Modeling ; Supercritical carbon dioxide ; Chiral isomers ; Cosolvents ; Experimental data ; Higher melting points ; Poorly-soluble drug ; Semiempirical equation ; Static flow ; Data reduction ; Isomers ; Melting point ; Models ; Supercritical fluid extraction ; Carbon dioxide ; Correlation ; Experimental study ; melting ; Methanol ; Numerical model ; Solubility ; Solvent ; Supercritical flow ; Temperature effect
  8. Source: Scientia Iranica ; Volume 19, Issue 3 , June , 2012 , Pages 619-625 ; 10263098 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S1026309812000338