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Electrochemical determinations of 6-mercaptopurine on the surface of a carbon nanotube-paste electrode modified with a cobalt salophen complex

Shahrokhian, S ; Sharif University of Technology | 2012

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  1. Type of Document: Article
  2. DOI: 10.1007/s10008-011-1575-5
  3. Publisher: 2012
  4. Abstract:
  5. A mixture of multi-walled carbon nanotube/graphite paste electrode modified with a salophen complex of cobalt was prepared and was applied for the study of the electrochemical behavior of 6-mercaptopurine (MP) using cyclic and differential pulse voltammetry (DPV). An excellent electrocatalytic activity toward the oxidation of MP was achieved, which led to a considerable lowering in the anodic overpotential and remarkable increase in the response sensitivity in comparison with unmodified electrode. Utilizing DPV method, a linear dynamic range of 1-100 μM with detection limit of 0.1 μM was obtained in phosphate buffer of pH 3.0. The electrochemical detection system was very stable, and the reproducibility of the electrode response, based on the six measurements during 1 month, was less than 3.0% for the slope of the calibration curves of MP. The electrochemical method as a simple, sensitive, and selective method was developed for the determination of MP in pharmaceutical dosage form and human plasma without any treatments
  6. Keywords:
  7. Carbon-paste electrode ; Cobalt (III) salophen complex ; 6-Mercaptopurine ; A-carbon ; Calibration curves ; Carbon paste electrode ; Detection limits ; Differential pulse voltammetry ; Electrocatalytic activity ; Electrochemical behaviors ; Electrochemical detection systems ; Electrochemical determination ; ELectrochemical methods ; Electrode response ; Human plasmas ; Linear dynamic ranges ; Modified electrodes ; Overpotential ; Paste electrodes ; Pharmaceutical dosage forms ; Phosphate buffers ; Reproducibilities ; Response sensitivity ; Salophen ; Anodic oxidation ; Carbon ; Cobalt ; Cobalt compounds ; Multiwalled carbon nanotubes (MWCN) ; Self assembly ; Voltammetry ; Electrochemical electrodes
  8. Source: Journal of Solid State Electrochemistry ; Volume 16, Issue 4 , April , 2012 , Pages 1643-1650 ; 14328488 (ISSN)
  9. URL: http://www.worldscientific.com/doi/abs/10.1142/S0218271812500393