Ultrasonic-assisted synthesis of magnetite based MRI contrast agent using cysteine as the biocapping coating

Ahmadi, R ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1016/j.matchemphys.2011.04.083
  3. Publisher: 2011
  4. Abstract:
  5. Magnetite nanoparticles (mean particle size ranging from 10 to 20 nm) were prepared by a biomoleculeassisted solution-phase approach under ultrasonic irradiation. Cysteine was used as the capping agent in the solution. The results show that cysteine could be an efficient biocapping agent in producing Fe3O4 nanoparticles. The crystal structure and magnetic properties of the nanoparticles were characterized by XRD and VSM techniques, respectively. FT-IR was used to investigate the presence of cysteine on the nanoparticles surface. The influence of pH value of the solution on the size distribution and hydrodynamic size of nanoparticles were studied by TEM and DLS methods, respectively. The MTT assay performed by incubation of L929 cells, showed the good biocompability of synthesized ferrofluids. In vitro T1 and T2 relaxivity measurements along with in vivo studies, which were conducted on rats, demonstrate that synthesized nanoparticles are applicable as the contrast agents, especially for imaging of the lymphatic system
  6. Keywords:
  7. (FT-IR) ; Electron microscopy ; Fourier transform infrared spectroscopy ; Nanostructures ; Biocompability ; Capping agent ; Contrast agent ; Fe3O4 nanoparticles ; Hydrodynamic size ; In-vitro ; In-vivo ; Influence of pH ; Lymphatic systems ; Mean particle size ; MRI contrast agents ; MTT assays ; Relaxivity ; Ultrasonic irradiation ; XRD ; Amino acids ; Magnetic fluids ; Magnetic materials ; Magnetic properties ; Nanoparticles ; Synthesis (chemical)
  8. Source: Materials Chemistry and Physics ; Volume 131, Issue 1-2 , 2011 , Pages 170-177 ; 02540584 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S025405841100678X