Application of a new spherical super element in predicting the deformation of biological cells in microinjection

Sarvi, M. N ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1115/DETC2011-47653
  3. Publisher: 2011
  4. Abstract:
  5. Biological cell injection is a sensitive and important work which is implemented in injection of foreign materials into individual cells. Microinjection is significantly developed in the field of drug discovery and genetics so predicting the behavior of cell in microinjection is remarkably important because a tiny excessive manipulation force can destroy the tissue of the biological cell. There are a few analytical methods available to simulate the cell injection, hence the numerical methods such as FEM are suitable to be used to model the microinjection. In this study, a new spherical super element is presented to model the biological cells and deformation of a specific cell under an external force is performed. The relationship between the injection force and the deformation of biological cell is demonstrated by using super element formulations. For validating the model, results are compared with findings of analytical and experimental methods. The advantage of this element is that only a few super elements can predict the static behavior of biological cell in microinjection properly instead of implementing a large number of conventional elements, so using the super element to model the cell can decrease the run time with suitable accuracy
  6. Keywords:
  7. Spherical super element ; Analytical method ; Biological cells ; Cell injection ; Drug discovery ; Experimental methods ; External force ; Foreign materials ; Individual cells ; Injection force ; Micro-injection ; Runtimes ; Static behaviors ; Super elements ; Cells ; Comminution ; Cytology ; Deformation ; Design ; Finite element method ; Forecasting ; Spheres ; Stress analysis ; Tissue ; Molecular biology
  8. Source: Proceedings of the ASME Design Engineering Technical Conference, 28 August 2011 through 31 August 2011 ; Volume 7 , August , 2011 , Pages 41-49 ; 9780791854846 (ISBN)
  9. URL: http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleid=1641150