Electrochemistry of levo-thyroxin on edge-plane pyrolytic graphite electrode: application to sensitive analytical determinations

Khafaji, M ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1002/elan.201100204
  3. Publisher: 2011
  4. Abstract:
  5. The electrochemical response of sodium levo-thyroxin (T4) at the surface of an edge plane pyrolytic graphite (EPPG) electrode is investigated using cyclic voltammetric technique in the presence of 0.1M HCl as supporting electrolyte. T4 underwent totally irreversible oxidation at this system and a well-defined peak at 821mV was obtained. Compared to the signals obtained in the optimized conditions at bare glassy carbon and carbon paste electrodes, the oxidation current of T4 at an EPPG electrode was greatly enhanced. The electrochemical process of T4 was explored and the experimental conditions were optimized. The oxidation peak current represented a linear dependence on T4 concentration from 0.01 to 10μM. The detection limit of 3nM (S/N=3) was obtained for 250s accumulation at 0.3V. Determination of T4 in a synthetic serum sample demonstrated that this sensor has good selectivity and high sensitivity
  6. Keywords:
  7. Analytical determination ; Cyclic voltammetry ; Edge plane pyrolytic graphite ; Levo-thyroxine
  8. Source: Electroanalysis ; Volume 23, Issue 8 , JUL , 2011 , Pages 1875-1880 ; 10400397 (ISSN)
  9. URL: http://onlinelibrary.wiley.com/doi/10.1002/elan.201100204/abstract;jsessionid=4971B32139B3BB78856DD4B3AB4E4E3A.f02t03