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Simulation of red blood cell motion in microvessels using modified moving particle semi-implicit method
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Simulation of red blood cell motion in microvessels using modified moving particle semi-implicit method

Ahmadian, M. T

Simulation of red blood cell motion in microvessels using modified moving particle semi-implicit method

Ahmadian, M. T ; Sharif University of Technology

551 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.scient.2011.12.007
  3. Abstract:
  4. Red Blood Cells (RBCs) are the main cells in human blood, with a main role in the mechanical properties of blood as a fluid. Several methods have been improved to simulate the mechanical behavior of RBC in micro-capillaries. Since, in microscopic scales, using discrete models is more preferred than continuum methods, the Moving Particle Semi-Implicit method (MPS), which is a recent innovative particle based method, can simulate micro-fluidic flows based on NavierStokes equations. Although, by recent developments, the MPS method has turned into a considerable tool for modeling blood flow in micro meter dimensions, some problems, such as a commitment to use small time step sizes, still restrict the method for large models and also for long time simulations. A new modified semi-implicit algorithm is developed and implemented on RBC motion through microvessels, in order to reduce calculation time by more than a factor of twenty, while the error of position and velocity remains constant. A two-dimensional, parallel plate, fluid flow is simulated based on the proposed method, and the effect of the calculation time decrement is evaluated. Findings indicate a reduction of 90 percent in simulation time compared to previous studies with the same results. This significant developed method could be applied to RBC interaction within micro-capillaries and constricted zones in blood flow
  5. Keywords:
  6. Micro-capillary ; Red blood cell ; Blood flow ; Calculation time ; Continuum method ; Discrete models ; Human bloods ; Mechanical behavior ; Micro-capillaries ; Microscopic scale ; Microvessels ; Moving particle semi-implicit ; Moving particle semiimplicit method ; Parallel plates ; Particle-based methods ; Semi-implicit ; Simulation time ; Time simulations ; Time step size ; Cells ; Hemodynamics ; Mechanical properties ; Blood vessels ; Algorithm ; Biomechanics ; Blood ; Cardiology ; Flow modeling ; Mechanical property ; Navier-Stokes equations ; Numerical model ; Velocity
  7. Source: Scientia Iranica ; Volume 19, Issue 1 , 2012 , Pages 113-118 ; 10263098 (ISSN)
  8. URL: http://www.sciencedirect.com/science/article/pii/S1026309811002628