Fluid particle diffusion through high-hematocrit blood flow within a capillary tube

Saadatmand, M ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jbiomech.2010.09.004
  3. Publisher: 2011
  4. Abstract:
  5. Fluid particle diffusion through blood flow within a capillary tube is an important phenomenon to understand, especially for studies in mass transport in the microcirculation as well as in solving technical issues involved in mixing in biomedical microdevices. In this paper, the spreading of tracer particles through up to 20% hematocrit blood, flowing in a capillary tube, was studied using a confocal micro-PTV system. We tracked hundreds of particles in high-hematocrit blood and measured the radial dispersion coefficient. Results yielded significant enhancement of the particle diffusion, due to a micron-scale flow-field generated by red blood cell motions. By increasing the flow rate, the particle dispersion increased almost linearly under constant hematocrit levels. The particle dispersion also showed near linear dependency on hematocrit up to 20%. A scaling analysis of the results, on the assumption that the tracer trajectories were unbiased random walks, was shown to capture the main features of the results. The dispersion of tracer particles was about 0.7 times that of RBCs. These findings provide good insight into transport phenomena in the microcirculation and in biomedical microdevices
  6. Keywords:
  7. Biofluid mechanics ; Capillary tube ; Confocal micro-PTV ; Red blood cell ; Biomedical microdevices ; Blood flow ; Fluid particles ; Linear dependency ; Mass transport ; Micron scale ; Particle diffusion ; Particle dispersion ; Radial dispersion ; Random Walk ; Scaling analysis ; Tracer particle ; Transport phenomena ; Atmospheric movements ; Blood ; Cells ; Diffusion in solids ; Dispersions ; Hemoglobin oxygen saturation ; Mechanics ; Portable equipment ; Transport properties ; Tubes (components) ; Blood vessels ; Confocal microscopy ; Controlled study ; Flow kinetics ; Flow rate ; Fluid particle diffusion ; Image analysis ; Molecular weight ; Particle size ; Priority journal ; Tube ; Biomechanics ; Capillaries ; Diffusion ; Erythrocytes ; Fluorescent Dyes ; Hematocrit ; Hemorheology ; Humans ; Microcirculation ; Microscopy, Confocal ; Microscopy, Video ; Models, Cardiovascular
  8. Source: Journal of Biomechanics ; Volume 44, Issue 1 , Jan , 2011 , Pages 170-175 ; 00219290 (ISSN)
  9. URL: http://www.jbiomech.com/article/S0021-9290(10)00490-2/abstract