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A facile synthesis of bridged polycyclic naphthooxazocine skeletons: Eight-membered-ring constructions via tandem dinucleophilic addition of naphthalenols to quinolinium salts

Matloubi Moghaddam, F ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1002/hlca.201000144
  3. Publisher: 2011
  4. Abstract:
  5. The efficient synthesis of bridged polycyclic naphthooxazocines 3 via addition of naphthalenols 1 as a bis-nucleophile to N-alkylquinolinium salts 2 is described (Scheme 1 and Table 2). This new approach provides a powerful entry into polycyclic structures containing bicyclic N,O-acetals related to bioactive compounds
  6. Keywords:
  7. 'Bis-nucleophile' ; Bioactive compounds ; Efficient synthesis ; Facile synthesis ; Naphthooxazocine ; New approaches ; Quinolinium salts ; Ring construction ; Tandem reaction ; Nucleophiles ; Synthesis (chemical) ; Salts ; N alkylquinolinium salt ; Naphthalenol ; Naphthol derivative ; Nucleophile ; Quinoline derivative ; Unclassified drug ; Priority journal ; Synthesis
  8. Source: Helvetica Chimica Acta ; Volume 94, Issue 1 , 2011 , Pages 142-147 ; 0018019X (ISSN)
  9. URL: http://onlinelibrary.wiley.com/doi/10.1002/hlca.201000144/abstract;jsessionid=B4D4EBE5AFEFCE1040AF9B6D271FEEF7.f02t01