Polyrotaxane capped quantum dots as new candidates for cancer diagnosis and therapy

Sarabi, R. S ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. Publisher: 2011
  3. Abstract:
  4. Molecular self-assembly of cadmium selenide quantum dots-end-capped polyrotaxane hybrid nanostructures (PRCdSe QDs) was led to a new type of core-shell hybrid nanomaterials consisting of cadmium selenide quantum dot (CdSe QDs) core and polyrotaxane shell (PR@QDs). Structure of PR@QDs was characterized using various techniques. It has been observed that the size of PR@QDs was between 20-25 nm in which diameter of core and thickness of shell were between 15-20 and 2-3 nm, respectively. Short-term in vitro cytotoxicity tests, using MTT (3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, were conducted on mouse tissue connective fibroblast adhesive cell line (L929) in order to investigate their potential application in nanomedicine and to understand the limitation and capability of these materials as nano-excipients in biological systems. All synthesized samples at low concentrations (i.e. 5μg/ml) maintained reasonable cell viability following exposure to cells; however, the particles show toxic behaviour at very high concentration (i.e. 1 mg/ml). Based on these experiments it was found that polyrotaxane shell on the surface of QDs could increase the internalization rate of the QDs into the cells, more than two times, in compare to that without conjugated cyclodextrin
  5. Keywords:
  6. α-cyclodextrin ; Hybrid nanomaterials ; Nanomedicine ; Quantum dot ; Adhesive cells ; Cadmium selenides ; Cancer diagnosis ; CdSe QDs ; Cell viability ; Core-shell hybrids ; High concentration ; Hybrid nanostructures ; In-vitro ; Low concentrations ; Molecular self assembly ; Mouse tissues ; Nanomedicines ; Polyrotaxanes ; Potential applications ; Bromine compounds ; Cadmium ; Cadmium alloys ; Cadmium compounds ; Cell culture ; Mammals ; Medical nanotechnology ; Nanostructured materials ; Shells (structures) ; Tissue ; Semiconductor quantum dots
  7. Source: Journal of Nanostructured Polymers and Nanocomposites ; Volume 7, Issue 1 , 2011 , Pages 18-31 ; 17904439 (ISSN)
  8. URL: http://www.academia.edu/2957600/Polyrotaxane_Capped_quantum_dots_as_new_candidates_for_cancer_diagnosis_and_therapy