RETRACTED ARTICLE: Study of stabilities of L-cysteine and L-methionine with divalent metal ions: A comparison of thermodynamic data

Sajadi, S. A. A ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1109/icbbe.2011.5780060
  3. Abstract:
  4. The acidity and stability constants of M-Met (M: M2+; Met 1: L-methionine) complexes, determined by potentiometric pH titrations, were used to make a comparative investigation with L-cysteine (Cys). It is shown that regarding to M ion - binding properties vital differences on complex bilding were considered. It is demonstrated, that in M-Met complexes, M ion is coordinated to the carboxyl group, M ion is also able to build macrochelate over amine group. The upmentioned results demonstrate that for M-Met complex the stability constants is also largly determined by the affinity of Cu2+ for amino group but in opposite to Met, some metal ions such as Co2+, Cu2+, and Zn2+ build with Cys 2 macrochelate over sulfur group. It is shown that this additional interaction with amino group and sulfur group can influence the character of some amino acid complexes in biological systems. The regarding △G°values are calculated and reported. The interesting point of this work is the △G° differences between M-Cys and M-Met complexes
  5. Keywords:
  6. Acidity and stability constants ; Cysteine ; Free energy ; Metal ion ; Methionine ; Binding energy ; Bioinformatics ; Biomedical engineering ; Cobalt compounds ; Complexation ; Coordination reactions ; Copper ; Metal ions ; Sulfur ; Amine groups ; Amino group ; Binding properties ; Carboxyl groups ; Divalent metal ion ; L-cysteine ; L-methionine ; PH titration ; Stability constants ; Thermodynamic data ; Amino acids
  7. Source: 5th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2011 ; 2011 ; 9781424450893 (ISBN)
  8. URL: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=5780060