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Optimization of Cell Proliferation on Polymeric Carriers Composed of Accelular Heart Matrix, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Abd Khodaei, Mohammad Jafar (Supervisor)
Abstract
Following heart coronary artery occlusion, heart stroke (HS) happens which leads to the creation of a dead zone on heart tissue named Myocardial Infarction (MI), the presence of which on a patient’s heart will result in succeeding HSs and the death of the patient. In this study, porous microcarriers capable of being utilized in cardiovascular tissue engineering is fabricated using a mixture of myocardium ectracellular matrix (ECM) and Chitosan (Cs). Results of Elasticity tests, SEM images, swelling behavior, biodegradability test, and cell proliferation assay showed that the scaffold consisting of 3.5% (w/w) Chitosan and 0.66% (w/w) ECM has the best potential in providing cardiovascular...
Cataloging briefOptimization of Cell Proliferation on Polymeric Carriers Composed of Accelular Heart Matrix, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Abd Khodaei, Mohammad Jafar (Supervisor)
Abstract
Following heart coronary artery occlusion, heart stroke (HS) happens which leads to the creation of a dead zone on heart tissue named Myocardial Infarction (MI), the presence of which on a patient’s heart will result in succeeding HSs and the death of the patient. In this study, porous microcarriers capable of being utilized in cardiovascular tissue engineering is fabricated using a mixture of myocardium ectracellular matrix (ECM) and Chitosan (Cs). Results of Elasticity tests, SEM images, swelling behavior, biodegradability test, and cell proliferation assay showed that the scaffold consisting of 3.5% (w/w) Chitosan and 0.66% (w/w) ECM has the best potential in providing cardiovascular...
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