Atherosclerosis in coronary arteries is one of the most important topics due to its high prevalence and the importance of these arteries for supplying blood to the heart. The morphology of endothelial cells (ECs) is an independent index for determining the atheroprone sites. The ECs show a regular elongated and aligned configuration to the blood flow, at the atheroprotected regions; on the other hand, at the atheroprone regions, the cells have a polygonal, randomly oriented morphology. The thesis intended to propose a method for coronary artery simulation, which is able to determine the atheroprone sites regarding the ECs morphology. In addition, the attempts were made to investigate the...