Identification of catecholamine neurotransmitters using fluorescence sensor array

Ghasemi, F ; Sharif University of Technology | 2016

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  1. Type of Document: Article
  2. DOI: 10.1016/j.aca.2016.02.037
  3. Publisher: Elsevier , 2016
  4. Abstract:
  5. A nano-based sensor array has been developed for identification and discrimination of catecholamine neurotransmitters based on optical properties of their oxidation products under alkaline conditions. To produce distinct fluorescence response patterns for individual catecholamine, quenching of thioglycolic acid functionalized cadmium telluride (CdTe) quantum dots, by oxidation products, were employed along with the variation of fluorescence spectra of oxidation products. The spectral changes were analyzed with hierarchical cluster analysis (HCA) and principal component analysis (PCA) to identify catecholamine patterns. The proposed sensor could efficiently discriminate the individual catecholamine (i.e., dopamine, norepinephrine, and l-DOPA) and their mixtures in the concentration range of 0.25-30 μmol L-1. Finally, we found that the sensor had capability to identify the various catecholamines in urine sample
  6. Keywords:
  7. Quantum dots ; Amines ; Cadmium telluride ; Cluster analysis ; Fluorescence ; Hierarchical systems ; Hormones ; Nanocrystals ; Neurophysiology ; Optical properties ; Oxidation ; Principal component analysis ; Semiconductor quantum dots ; Sensor arrays ; Alkaline conditions ; Catecholamine neurotransmitters ; Concentration ranges ; Fluorescence sensor arrays ; Fluorescence spectra ; Hierarchical cluster analysis ; Oxidation products ; Oxidized catecholamines ; Norepinephrine
  8. Source: Analytica Chimica Acta ; Volume 917 , April , 2016 , Pages 85–92 ; 00032670 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0003267016302744