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Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples
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Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples

Nezhadali, A

Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples

Nezhadali, A ; Sharif University of Technology | 2015

506 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.talanta.2015.06.082
  3. Publisher: Elsevier , 2015
  4. Abstract:
  5. Abstract A sensitive electrochemical sensor for determination of phenothiazine (PTZ) was introduced based on molecularly imprinted polymer (MIP) film. A computational study was performed to evaluate the template-monomer geometry and interaction energy in the prepolymerization mixture. The electrode was prepared during electropolymerization of pyrrole (Py) on a pencil graphite electrode (PGE) by cyclic voltammetry (CV) technique. The quantitative measurements were performed using differential pulse voltammetry (DPV) in Britton-Robinson (BR) buffer solutions using 60% (v/v) acetonitrile-water (ACN/H2O) binary solvent. The effect of important parameters like pH, monomer concentration, number of cycles, etc on the efficiency of MIP electrode was optimized and the calibration curve was plotted at optimal conditions. Two dynamic linear ranges of 1-300 μmol L-1 and 0.5-10 mmol L-1 were observed. The detection limit (based on S/N=3) of PTZ was obtained 3×10-7 mol L-1. The MIP/PGE has been successfully applied as a selective sensor for fast and accurate determination of PTZ in some model and real biological samples
  6. Keywords:
  7. Chemical detection ; Computational geometry ; Copolymers ; Curve fitting ; Cyclic voltammetry ; Electrochemical sensors ; Electrodes ; Electropolymerization ; Graphite ; Graphite electrodes ; Insecticides ; Monomers ; Organic solvents ; Polypyrroles ; Voltammetry ; Differential pulse voltammetry ; Electrochemical preparation ; Molecularly Imprinted Polymer ; Molecularly imprinted polymer films ; Molecularly imprinted polypyrrole ; Pencil graphite electrode ; Phenothiazine (PTZ) ; Quantitative measurement ; Electrochemical electrodes
  8. Source: Talanta ; Volume 144 , November , 2015 , Pages 456-465 ; 00399140 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0039914015301144