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Electrochemical determination of piroxicam on the surface of pyrolytic graphite electrode modified with a film of carbon nanoparticle-chitosan

Shahrokhian, S ; Sharif University of Technology | 2010

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  1. Type of Document: Article
  2. DOI: 10.1007/s00604-010-0373-6
  3. Publisher: 2010
  4. Abstract:
  5. The electrochemical behavior of the anti-inflammatory drug piroxicam is studied at the surface of a plain pyrolytic graphite electrode modified with chitosan-doped carbon nanoparticles. An electroactive surface was produced by drop-casting a suspension of the modifier and characterized by atomic force microscopy. A remarkable enhancement is found in studies on the cyclic voltammetric response towards piroxicam. This is described on the basis of the thin-layer mass transport regimes within the porous films, which leads to a considerable increase in the active surface area of the electrode. The electrode shows a linear response to piroxicam in the range of 0.05-50 μM, with a detection limit of 25 nM (at S/N of 3). The electrode was successfully applied to the determination of piroxicam in pharmaceutical and clinical preparations with satisfactory accuracy and precision
  6. Keywords:
  7. Carbon nanoparticles ; Chitosan ; Cyclic voltammetry ; Modified electrode ; Piroxicam
  8. Source: Microchimica Acta ; Volume 170, Issue 1 , August , 2010 , Pages 141-146 ; 00263672 (ISSN)
  9. URL: http://link.springer.com/article/10.1007%2Fs00604-010-0373-6