Poly(citric acid)-block-poly(ethylene glycol) copolymers-new biocompatible hybrid materials for nanomedicine

Tavakoli Naeini, A ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.nano.2009.11.008
  3. Abstract:
  4. Linear-dendritic ABA triblock copolymers containing poly(ethylene glycol) (PEG) as B block and hyperbranched poly(citric acid) (PCA) as A blocks were synthesized through polycondensation. The molecular self-assembly of synthesized PCA-PEG-PCA copolymers in water led to formation of nanoparticles and fibers in different sizes and shapes depending on the time and size of PCA blocks. Ten days after dissolving PCA-PEG-PCA copolymers in water, the size of fibers had reached several millimeters. Mixing a water solution of fluorescein as a small guest molecule and PCA-PEG-PCA copolymers led to the encapsulation of fluorescein by products of molecular self-assembly. To investigate their potential application in nanomedicine and to understand the limitations and capabilities of these materials as nanoexcipients in biological systems, different types of short-term in vitro cytotoxicity experiments on the HT1080 cell line (human fibrosarcoma) and hemocompatibility tests were performed. From the Clinical Editor: This manuscript investigates the potentials of linear-dendritic ABA triblock copolymers containing poly(ethylene glycol) (PEG) as B block and hyperbranched poly(citric acid) (PCA) as A blocks for future applications in nanomedicine
  5. Keywords:
  6. Encapsulation ; Linear-dendritic ; ABA triblock copolymer ; Different sizes ; Future applications ; Guest molecules ; Hemocompatibility ; HT-1080 cells ; Hyperbranched ; In-vitro ; Molecular self assembly ; Potential applications ; Water solutions ; Acids ; Assembly ; Biological materials ; Block copolymers ; Cell culture ; Citric acid ; Copolymerization ; Dendrimers ; Dissolution ; Ethylene ; Ethylene glycol ; Hybrid materials ; Medical nanotechnology ; Plastic products ; Polycondensation ; Polyethylene oxides ; Self assembly ; Polyethylene glycols ; Copolymer ; Fluorescein ; Macrogol ; Poly(citric acid) ; Polymer ; Unclassified drug ; Water ; Atomic force microscopy ; Biocompatibility ; Controlled study ; Cytotoxicity ; Gel permeation chromatography ; In vitro study ; Matrix assisted laser desorption ionization time of flight mass spectrometry ; Molecular weight ; Particle size ; Protein assembly ; Time of flight mass spectrometry ; Biocompatible Materials ; Cell Line, tumor ; Drug delivery systems ; Humans ; Nanomedicine ; Nanoparticles ; Polyesters
  7. Source: Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 6, Issue 4 , Aug , 2010 , Pages 556-562 ; 15499634 (ISSN)
  8. URL: http://www.nanomedjournal.com/article/S1549-9634(10)00007-9/abstract