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Synthesis of eight-membered hydroquinolines related to alkaloid skeletons via addition of 4-hydroxycoumarin or 4-hydroxypyran-2-one to quinolinium salts

Matloubi Moghaddam, F ; Sharif University of Technology | 2010

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  1. Type of Document: Article
  2. DOI: 10.1016/j.tet.2010.03.078
  3. Publisher: 2010
  4. Abstract:
  5. A new one-pot synthesis of hitherto unknown polyheterocyclic systems via tandem C-alkylation and intramolecular O-alkylation of 4-hydroxycoumarin or 4-hydroxypyran-2-one with quinolinium salts in excellent yields (71-89%) is reported. The present approach provides a powerful route into polycyclic structures containing nitrogen and oxygen related to alkaloids
  6. Keywords:
  7. 4 hydroxycoumarin ; Nitrogen ; Oxygen ; Pyran derivative ; Quinoline derivative ; Sodium chloride ; Alkylation ; Chemical structure ; One pot synthesis ; Priority journal ; Alkaloid
  8. Source: Tetrahedron ; Volume 66, Issue 21 , Jan , 2010 , Pages 3678-3681 ; 00404020 (ISSN)
  9. URL: https://www.mysciencework.com/publication/show/d9f1262062468bb87e6d08da7335e32e