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A new and convenient approach to heterotetracyclic benzoxazocines through addition of 1,3-dicarbonyl compounds to quinolinium salts

Matloubi Moghaddam, F ; Sharif University of Technology | 2010

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  1. Type of Document: Article
  2. DOI: 10.1016/j.tetlet.2010.03.038
  3. Publisher: 2010
  4. Abstract:
  5. The synthesis of a series of benzoxazocines has been achieved in good yields by tandem C-alkylation and intramolecular O-alkylation of 1,3-dicarbonyl compounds with quinolinium salts. This is a novel example of the synthesis of eight-membered rings via a tandem process, which provides a method for the synthesis of medium-ring heterocycles
  6. Keywords:
  7. Alkaloid ; Benzoxazocine derivative ; Carbonyl derivative ; Quinoline ; Unclassified drug ; Alkylation ; Cyclization ; Drug structure ; Drug synthesis ; Heteronuclear multiple bond correlation ; Reaction optimization
  8. Source: Tetrahedron Letters ; Volume 51, Issue 20 , April , 2010 , Pages 2704-2707 ; 00404039 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0040403910004594