Modeling of Blood Flow and Deposition of Low Density Lipoprotein (LDL) in Coronary Arteries

Emami Meybodi, Ali | 2016

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 49263 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Firoozabadi, Bahar; Saidi, Mohammad Said
  7. Abstract:
  8. In this thesis, hemodynamic parameters of flow and deposition of low density lipoproteins (LDL) on wall of coronary arteries with taking into account their curvature on the heart are studied. At first, numerical solution of the blood flow by assumption of blood as incompressible and Newtonian fluid for steady and pulsatile inlet is done. Then by assuming LDL particles as dilute solute in the blood, LDL transport from artery lumen into arterial wall is studied. LDL accumulation and penetration into the vessel wall cause thickening of the walls and eventually eclipse it and its known as the first stage of atherosclerosis disease. The results show that low shear region occurs on inner wall (myocardial) and near the bifurcation. Also, in these areas, the higher accumulation of LDL on artery wall is obtained. Based on these results and the effect of hemodynamic factors on the endothelium cells of artery wall in the experimental findings, in the next step, shear-dependant permeability of wall is applied to the model. In this case, the results show the increase of LDL accumulation at high risk areas near the bifurcation. In addition pulsatile flow at inlet cause temporal changes of shear rate on artery wall. Shear-dependant permeability model better take into account effect of these changes on LDL deposition
  9. Keywords:
  10. Atherosclerosis ; Coronary Artery ; Mass Transfer ; Low Density Lipoprotein (LDL) ; Blood Flow

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