Graphene/cobalt nanocarrier for hyperthermia therapy and MRI diagnosis

Hatamie, S ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.colsurfb.2016.06.018
  3. Publisher: Elsevier
  4. Abstract:
  5. Graphene/cobalt nanocomposites are promising materials for theranostic nanomedicine applications, which are defined as the ability to diagnose, provide targeted therapy and monitor the response to the therapy. In this study, the composites were synthesized via chemical method, using graphene oxide as the source material and assembling cobalt nanoparticles of 15 nm over the surface of graphene sheets. Various characterization techniques were then employed to reveal the morphology, size and structure of the nanocomposites, such as X-ray diffraction analysis, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, high resolution transmission electron microscopy and ultraviolet visible spectroscopy. Using ion-coupled plasma optical emission spectroscopy, cobalt concentration in the nanocomposites was found to be 80%. In addition, cytotoxicity of graphene/cobalt nanocomposites were evaluated using 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide or MTT assay. MTT viability assay exhibited biocompatibility to L929 mouse fibroblasts cells, under a high dose of 100 μg/mL over 24 h. Hyperthermia results showed the superior conversion of electromagnetic energy into heat at 350 kHz frequency for 0.01 and 0.005 g/L of the nanocomposites solution. The measured heat generation and energy transfer results were anticipated by the finite element analysis, conducted for the 3D structure. Magnetic resonance imaging characteristics also showed that negatively charge graphene/cobalt nanocomposites are suitable for T1-weighted imaging
  6. Keywords:
  7. Graphene/cobalt nanocomposites ; Hyperthermia ; MRI contrast agents ; Biocompatibility ; Characterization ; Electromagnetic waves ; Energy transfer ; Finite element method ; Fourier transform infrared spectroscopy ; Graphene ; High resolution transmission electron microscopy ; Hyperthermia therapy ; Magnetic resonance imaging ; Medical nanotechnology ; Nanocomposites ; Optical emission spectroscopy ; Spectrum analysis ; Synthesis (chemical) ; Ultraviolet visible spectroscopy ; X- ray diffraction analysis ; Cancer therapy ; Characterization techniques ; Cobalt concentration ; Cobalt nanoparticles ; Mouse-fibroblasts ; MRI contrast agents ; Theranostic nanomedicine ; X-ray photoelectron spectroscopy ; Drug carrier ; Graphite ; Animal ; Cell culture ; Chemistry ; Cytology ; Fibroblast ; Infrared spectroscopy ; Mouse ; Nuclear magnetic resonance imaging ; Procedures ; Thermotherapy ; Transmission electron microscopy ; Animals ; Cells, cultured ; Cobalt ; Drug carriers ; Hyperthermia, induced ; Mice ; Microscopy, eectron, transmission ; Spectroscopy, fourier transform infrared ; X-Ray diffraction
  8. Source: Colloids and Surfaces B: Biointerfaces ; Volume 146 , 2016 , Pages 271-279 ; 09277765 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0927776516304489