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Chemical modification of the electrode surface by composites of Ag Nanoparticle Decorated on Multi Walled Carbon Nanotube; Application to Investigate the Electrochemical behavior and Determination of Risperidone and Isoxsuprine drugs

Hafezi Kahnamoui, Mohammad | 2017

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 49956 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Shahrokhian, Saeed
  7. Abstract:
  8. Nowadays, electrochemical sensors have numerous benefits, including simplicity,low cost, high selectivity and high sensitivity as an efficient and useful tool in various fields such as the environment, disease diagnostics, medical and medical surveillance, and Anti-terrorism security systems have become the focus of attention in the field of analytical measurements. In the meantime, carbon nanostructures and metal nanoparticles have been considered as suitable alternatives in order to improve their surface properties due to their unique electronic properties and mechanical and chemical stability. Since the determination of trace amounts of pharmaceutical and biological compounds is very important, in this research, the glassy carbon electrode surface was modified by carbon nanotubes and metal nanoparticles and used for electrochemical studies and drug measurement In the first work, a modified glassy carbon electrode with a film of carbon nano tube decorated with Ag nanoparticles was constructed and used for sensitive voltammetric
    determination and investigation of Isoxsuprine (ISOX). Then, the prepared nanocomposite was characterized by electron microscopy, spectroscopy and electrochemical techniques.With modification of the surface of the glassy carbon electrode by modifier and optimization of the experimental parameters such as deposited amount of the modifier suspension, pH of the supporting electrolyte and accumulation potential and time, significant voltammetric response was observed for oxidation of ISOX compared to unmodified electrode, These results illustrate that the modified electrode increased the effective surface area and exhibited an excellent catalytic effect in the electro-oxidation of ISOX. Under the optimum conditions, the modified electrode showed a linear response to the concentration of ISOX in the range of 0.04–5 µM with a detection limit of 12 nM. The prepared modified electrode has some remarkable electrochemical properties such as simple preparation, high sensitivity, excellent repeatability, reproducibility and long–term stability and used for determinations in pharmaceutical and clinical samples.In the second work, a comparison between different carbon nanostructures was conducted to find a stable, sensitive and repeatable surface toward Risperidone(RIS).MWCNTs selected as a carbon nanostructure that created these parameters.. Finally, with attention to parameters such as remarkable increase in analytical signals, sensitivity,stability and repeatability toward RIS response, MWCNTs/GCE chose as a promising candidate for the trace analysis of RIS in pharmaceutical and clinical preparations. Experimentally parameters (accumulation time and potential deposition, film thickness of the modifier, pH of the supporting electrolyte) were optimized and under these conditions,linear response for RIS in the range of 0.04-7 µM with detection limit of 12 nM was obtained. The modified electrode was successfully applied for the accurate determination of trace amounts of RIS in pharmaceutical and clinical preparations. Also, in the presence of some potentially interference, this modified electrode was tasted and suitable results was achieved
  9. Keywords:
  10. Glassy Carbon Electrode ; Silver Nanoparticles ; Carbon Nanostructures ; Multi-Walled Carbon Nanotube ; Chemical Modification ; Electrochemical Behavior ; Voltammetric Measurement ; Modified Electrodes ; Risperidone ; Isoxsuprine

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