Hybrid multiscale modeling and prediction of cancer cell behavior

Zangooei, M. H ; Sharif University of Technology | 2017

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  1. Type of Document: Article
  2. DOI: 10.1371/journal.pone.0183810
  3. Publisher: Public Library of Science , 2017
  4. Abstract:
  5. Background: Understanding cancer development crossing several spatial-temporal scales is of great practical significance to better understand and treat cancers. It is difficult to tackle this challenge with pure biological means. Moreover, hybrid modeling techniques have been proposed that combine the advantages of the continuum and the discrete methods to model multiscale problems. Methods: In light of these problems, we have proposed a new hybrid vascular model to facilitate the multiscale modeling and simulation of cancer development with respect to the agent-based, cellular automata and machine learning methods. The purpose of this simulation is to create a dataset that can be used for prediction of cell phenotypes. By using a proposed Q-learning based on SVR-NSGA-II method, the cells have the capability to predict their phenotypes autonomously that is, to act on its own without external direction in response to situations it encounters. Results: Computational simulations of the model were performed in order to analyze its performance. The most striking feature of our results is that each cell can select its phenotype at each time step according to its condition. We provide evidence that the prediction of cell phenotypes is reliable. Conclusion: Our proposed model, which we term a hybrid multiscale modeling of cancer cell behavior, has the potential to combine the best features of both continuum and discrete models. The in silico results indicate that the 3D model can represent key features of cancer growth, angiogenesis, and its related micro-environment and show that the findings are in good agreement with biological tumor behavior. To the best of our knowledge, this paper is the first hybrid vascular multiscale modeling of cancer cell behavior that has the capability to predict cell phenotypes individually by a self-generated dataset. © 2017 Zangooei, Habibi. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
  6. Keywords:
  7. Article ; Cancer cell ; Cell function ; Hybrid multiscale modeling ; Machine learning ; Mathematical computing ; Mathematical model ; Phenotype ; Prediction ; Reliability ; Simulation ; Support vector machine ; Biological model ; Cell motion ; Human ; Metabolism ; Necrosis ; Neoplasm ; Pathology ; Epidermal growth factor receptor ; Tumor necrosis factor ; Tumor necrosis factor receptor ; Vasculotropin A ; Apoptosis ; Cell hypoxia ; Cell Movement ; Cell proliferation ; Computer simulation ; Humans ; Models, Biological ; Necrosis ; Neoplasms ; Receptor, epidermal growth factor ; Receptors, tumor necrosis factor ; Signal transduction ; Tumor necrosis factor-alpha ; Vascular endothelial growth factor A
  8. Source: PLoS ONE ; Volume 12, Issue 8 , 2017 ; 19326203 (ISSN)
  9. URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183810