Glassy carbon electrode modified with 3D graphene–carbon nanotube network for sensitive electrochemical determination of methotrexate

Asadian, E ; Sharif University of Technology | 2017

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  1. Type of Document: Article
  2. DOI: 10.1016/j.snb.2016.08.064
  3. Publisher: Elsevier B.V , 2017
  4. Abstract:
  5. In the present study, a 3D porous graphene-carbon nanotube (G-CNT) network is successfully constructed on the surface of glassy carbon electrode (GCE) by electrochemical co-deposition from a concentrated graphene dispersion. The large accessible surface area provided by the interpenetrated graphene backbone in one hand and the enhanced electrical conductivity of the 3D network by incorporating CNTs on the other hand, dramatically improved the electrochemical performance of GCE in determination of Methotrexate (MTX) as an important electroactive drug compound. Under the optimum conditions, the electrode modification led to a significant increase in the anodic peak current (∼25 times) along with a considerable shift in the peak potential (∼111 mV). Voltammetric investigations revealed that the proposed method can determine MTX in a wide dynamic linear range with a low detection limit of 70 nM. Moreover, good sensitivity and high accuracy of the prepared modified electrode in voltammetric detections of MTX, which was further confirmed by UV–vis spectroccopy and HPLC methods, make it very suitable for accurate determinations of MTX in pharmaceutical formulations (commercial tablets) and clinical preparations (blood serum) with excellent recoveries. © 2016 Elsevier B.V
  6. Keywords:
  7. 3D-Network ; Carbon nanotube ; Electrodeposition ; Methotrexate ; Carbon nanotubes ; Chemical detection ; Deposition ; Electrochemical electrodes ; Electrodes ; Glass ; Graphene ; Nanotubes ; Voltammetry ; Yarn ; 3D networks ; Accessible surface areas ; Electrochemical determination ; Electrochemical performance ; Glassy carbon electrodes ; Pharmaceutical formulation ; Voltammetric investigation ; Glass membrane electrodes
  8. Source: Sensors and Actuators, B: Chemical ; Volume 239 , 2017 , Pages 617-627 ; 09254005 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0925400516312965