Nanocaged platforms: Modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger

Sahandi Zangabad, P ; Sharif University of Technology | 2017

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  1. Type of Document: Article
  2. DOI: 10.1039/c6nr07315h
  3. Publisher: Royal Society of Chemistry , 2017
  4. Abstract:
  5. Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe). In this review, we cover different classes of NC structures such as virus-like particles (VLPs), protein NCs, DNA NCs, supramolecular nanosystems, hybrid metal-organic NCs, gold NCs, carbon-based NCs and silica NCs. Moreover, NC-assisted drug delivery including modification methods, drug immobilization, active targeting, and stimulus-responsive release mechanisms are discussed, highlighting the advantages, disadvantages and challenges. Finally, translation of NCs into clinical applications, and an up-to-date assessment of the nanotoxicology considerations of NCs are presented. © 2017 The Royal Society of Chemistry
  6. Keywords:
  7. Chemotherapy ; Organometallics ; Viruses ; Active targeting ; Anti-cancer chemotherapy ; Clinical application ; Medical treatment ; Modification methods ; Porous structures ; Release mechanism ; Virus-like particles ; Carbon
  8. Source: Nanoscale ; Volume 9, Issue 4 , 2017 , Pages 1356-1392 ; 20403364 (ISSN)
  9. URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010924564&doi=10.1039%2fc6nr07315h&partnerID=40&md5=f749c9727868f1ad30e8ac78d2fb20db