Investigation of the electrochemical behavior of tizanidine on the surface of glassy carbon electrode modified with multi-walled carbon nanotube/titan yellow–doped polypyrrole

Shahrokhian, S ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jelechem.2018.06.005
  3. Abstract:
  4. The present paper describes a voltammetric sensor based on glassy carbon electrode (GCE) modified with a thin film of multi-walled carbon nanotubes (MWCNTs) coated with an electro-polymerized layer of titan yellow-doped over–oxidized polypyrrole (OPPY) for the determination of tizanidine (TIZ). A significant enhancement was observed in the anodic peak current of TIZ on the surface of OPPY/CNT/GCE, relative to the bare, CNT- and OPPY-coated GCEs. The microscopic structure and surface morphology of the composite film was thoroughly characterized by means of atomic force microscopy (AFM), scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques. The effect of various experimental parameters, such as pH of the supporting electrolyte, drop size of the casted MWCNTs suspension, number of electro-polymerization cycles and accumulation time were investigated by monitoring the LSV responses of TIZ. In the optimal conditions, the modified electrode showed two linear dynamic ranges of 0.01–1.0 μM and 1.0–10 μM with a detection limit of 3 nM for the voltammetric determination of TIZ. Besides high sensitivity, the fabricated sensor represented high stability and good reproducibility for TIZ analysis. These properties made the prepared sensor suitable for the accurate determination of trace amounts of TIZ in pharmaceutical and clinical preparations. © 2018 Elsevier B.V
  5. Keywords:
  6. Atomic force microscopy ; Carbon nanotubes ; Composite films ; Cyclic voltammetry ; Electrolytes ; Film preparation ; Glass ; Glass membrane electrodes ; Polypyrroles ; Scanning electron microscopy ; Yarn ; Composite modified electrodes ; Electrochemical behaviors ; Experimental parameters ; Glassy carbon electrodes ; Overoxidized polypyrrole ; Supporting electrolyte ; Tizanidine ; Voltammetric determination ; Multiwalled carbon nanotubes (MWCN)
  7. Source: Journal of Electroanalytical Chemistry ; Volume 823 , 2018 , Pages 146-154 ; 15726657 (ISSN)
  8. URL: https://www.sciencedirect.com/science/article/pii/S157266571830420X