A Physiological model-based study of flow-mediated dilation in peripheral arteries using finger photoplethysmogram signal

Habib Parsafar, M ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1109/ICBME.2017.8430257
  3. Abstract:
  4. Flow-mediated dilation measurement in the brachial artery using ultrasound imaging (FMD-US) is a common noninvasive procedure for endothelial function evaluation in the peripheral arteries. As FMD-US is operator-dependent and involves onerous equipment, its use has been mostly confined to research settings. In this paper, we propose to use the more accessible finger photoplethysmogram signal in conjunction with the FMD test (FMD-PPG) as a surrogate method. To this end, a tube-load physiological model of the upper arterial path in the arm is developed. Signals acquired from young and elderly subjects (N=20) are then investigated using model parameter estimation by the genetic algorithm. Our results show that the estimated parameter values for the elderly group in baseline are significantly different from that in the young group (p<0.05), and the parameter changes in cuff release interval are consistent with existing literature. Therefore, the presented FMD-PPG may hold a great potential in non-invasively assessing the endothelial function. © 2017 IEEE
  5. Keywords:
  6. Cardiovascular modeling ; Physiological model ; Tube-load model ; Biomedical engineering ; Biophysics ; Genetic algorithms ; Noninvasive medical procedures ; Parameter estimation ; Physiology ; Ultrasonic imaging ; Cardiovascular models ; Endothelial function ; Estimated parameter ; Flow mediated dilation ; Load modeling ; Model parameter estimation ; Peripheral arteries ; Photo-plethysmogram ; Physiological models
  7. Source: 2017 24th Iranian Conference on Biomedical Engineering and 2017 2nd International Iranian Conference on Biomedical Engineering, ICBME 2017, 30 November 2017 through 1 December 2017 ; 2018 ; 9781538636091 (ISBN)
  8. URL: https://ieeexplore.ieee.org/abstract/document/8430257