Numerical and experimental evaluation of high-intensity focused ultrasound-induced lesions in liver tissue ex vivo

Haddadi, S ; Sharif University of Technology | 2018

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  1. Type of Document: Article
  2. DOI: 10.1002/jum.14491
  3. Publisher: 2018
  4. Abstract:
  5. OBJECTIVES: Recent advances in the field of acoustics and piezoelectric and ultrasound transducers have led to new approaches to the diagnosis and treatment of certain diseases. One method of treatment with ultrasonic waves is high-intensity focused ultrasound (HIFU) treatment, which is a thermal therapeutic method used to treat malignant tumors. Although a variety of treatment-planning strategies using ultrasonic waves have been investigated, little clinical success has been achieved. Computational modeling is a powerful tool for predicting device performance. METHODS: The heating induced by a concave transducer with operating powers of 85 and 135 W was studied, and the experimental results presented in this article verify its applicability. Numerical simulations of the nonlinear acoustic field were performed by using the Westervelt and Khokhlov-Zabolotskaya-Kuznetsov equations. Heat transfer was measured for the 2 operational powers, and the results were compared with ex vivo experimental results. In addition, thermal dose contours for both the simulation and experimental results were calculated to investigate the ablated area. RESULTS: Good agreement was found between the experimental and numerical results. The results show that the average temperature deviations calculated at the focal point were 12.8% and 4.3% for transducer powers of 85 and 135 W, respectively. CONCLUSIONS: This study provides guidance to HIFU practitioners in determining lesion size and identifying nonlinear effects that should be considered in HIFU procedures. © 2017 by the American Institute of Ultrasound in Medicine
  6. Keywords:
  7. High-intensity focused ultrasound/sonoporation ; Khokhlov-Zabolotskaya-Kuznetsov equation ; Nonlinear wave propagation ; Pennes bioheat equation ; Westervelt equation ; Animal ; Animal model ; Heat ; High intensity focused ultrasound ; Surgery ; Animals ; Computer Simulation ; High-Intensity Focused Ultrasound Ablation ; Hot Temperature ; Liver ; Models, Animal ; Sheep
  8. Source: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine ; Volume 37, Issue 6 , 2018 , Pages 1481-1491 ; 15509613 (ISSN)
  9. URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jum.14491