Loading...

Evaluation of UiO-66 metal organic framework as an effective sorbent for curcumin's overdose

Molavi, H ; Sharif University of Technology | 2018

864 Viewed
  1. Type of Document: Article
  2. DOI: 10.1002/aoc.4221
  3. Publisher: John Wiley and Sons Ltd , 2018
  4. Abstract:
  5. Metal organic frameworks (MOFs) UiO-66 (UiO stands for University of Oslo) and NH2-UiO-66 were prepared and characterized as sorbent (antidotal agents) for curcumin (CUR) adsorption. The structure of products were characterized by X-ray powder diffraction (XRD), Field emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA), Attenuated Total Reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and N2 adsorption–desorption measurements. FESEM showed NH2-UiO-66 displayed symmetrical crystals with triangular base pyramid morphology, with the particle size around 100 nm and uniform size distribution. Adsorption capacities of CUR/MOFs with different mass ratios in the feed were investigated in the present study, and this investigation revealed that when the CUR/MOFs with mass ratio was around 0.4, the absorption capacity of NH2-UiO-66 had tended to maximum. Although, functionalization reduced the specific surface area and free volume, introducing polar amine groups could improve the affinity of NH2-UiO-66 respect to CUR. Kinetic studies showed that the kinetic data are well fitted with the pseudo- second-order model. MTT assay revealed that MOFs at the concentration range of 0–560 μg/ml had no cytotoxic effect on the Human Foreskin Fibroblast normal cell line (HFF-2). These results suggest that these MOFs could be safe as sorbent for adsorb CUR from the body. Copyright © 2018 John Wiley & Sons, Ltd
  6. Keywords:
  7. Sorbent ; Adsorption ; Cell culture ; Crystalline materials ; Cytotoxicity ; Field emission microscopes ; Fourier transform infrared spectroscopy ; Organic polymers ; Organometallics ; Particle size ; Scanning electron microscopy ; Sorbents ; Sorption ; X ray powder diffraction ; Antidote ; Attenuated total reflectance fourier transform infrared spectroscopies (ATR FTIR) ; Field emission scanning electron microscopy ; Metal organic framework ; Metalorganic frameworks (MOFs) ; Overdose ; Pseudo-second order model ; UiO-66 ; Thermogravimetric analysis
  8. Source: Applied Organometallic Chemistry ; Volume 32, Issue 4 , 2018 ; 02682605 (ISSN)
  9. URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/aoc.4221