Drug delivery systems and materials for wound healing applications

Saghazadeh, S ; Sharif University of Technology | 2018

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  1. Type of Document: Article
  2. DOI: 10.1016/j.addr.2018.04.008
  3. Publisher: Elsevier B.V , 2018
  4. Abstract:
  5. Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted. © 2018 Elsevier B.V
  6. Keywords:
  7. Drug delivery ; Microtechnologies ; Nanotechnologies ; Transdermal delivery ; Wound healing ; Nanotechnology ; Targeted drug delivery ; Tissue regeneration ; Degradative enzymes ; Emerging technologies ; Micro technology ; Physiological process ; Wound healing applications ; Controlled drug delivery ; Alginic acid ; Biomaterial ; Drug carrier ; Gelatin ; Lipid ; Photosensitizing agent ; Polymer ; Vasculotropin ; Chronic wound ; Controlled drug release ; Drug delivery system ; Electrospinning ; Foam ; Human ; Hydrogel ; Pathophysiology ; Physiology ; Review ; Wound care
  8. Source: Advanced Drug Delivery Reviews ; Volume 127 , 2018 , Pages 138-166 ; 0169409X (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0169409X18300607