Simulation of low density lipoprotein (LDL) permeation into multilayer coronary arterial wall: interactive effects of wall shear stress and fluid-structure interaction in hypertension

Roustaei, M ; Sharif University of Technology | 2018

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jbiomech.2017.11.029
  3. Publisher: Elsevier Ltd , 2018
  4. Abstract:
  5. Due to increased atherosclerosis-caused mortality, identification of its genesis and development is of great importance. Although, key factors of the origin of the disease is still unknown, it is widely believed that cholesterol particle penetration and accumulation in arterial wall is mainly responsible for further wall thickening and decreased rate of blood flow during a gradual progression. To date, various effective components are recognized whose simultaneous consideration would lead to a more accurate approximation of Low Density Lipoprotein (LDL) distribution within the wall. In this research, a multilayer Fluid-Structure Interaction (FSI) model is studied to simulate the penetration of LDL into the arterial wall. Distention impact on wall properties is taken into account by considering FSI and Wall Shear Stress (WSS) dependent endothelium properties. The results show intensified permeation of LDL whilst the FSI approach is applied. In addition, luminal distension prompted by FSI reduces WSS along lumen/wall interface, especially in hypertension. This effect leads to a lowered endothelial resistance against LDL permeation, comparing to the case in which WSS effect is overlooked. The results are in an acceptable consistency with the clinical researches on WSS effect on atherosclerosis development. © 2017 Elsevier Ltd
  6. Keywords:
  7. FSI ; LDL ; WSS ; Blood vessels ; Clinical research ; Diseases ; Lipoproteins ; Multilayers ; Shear flow ; Shear stress ; Atherosclerosis ; Coronary ; Interactive effect ; Low density lipoproteins ; Particle penetration ; Wall properties ; Wall shear stress ; Wall thickening ; Low density lipoprotein ; Arterial wall thickness ; Artery dilatation ; Artery endothelium ; Artery permeability ; Cell membrane permeability ; Comparative effectiveness ; Concentration (parameters) ; Controlled study ; Coronary artery ; Diffusivity ; Endothelium ; Endothelium cell ; Fluid structure interaction ; Hypertension ; Mathematical model ; Measurement accuracy ; Physical phenomena ; Priority journal ; Protein transport ; Steady state ; Thermodynamics ; Velocity
  8. Source: Journal of Biomechanics ; Volume 67 , 2018 , Pages 114-122 ; 00219290 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S002192901730684X