Enhanced chondrogenic differentiation of human bone marrow mesenchymal stem cells on PCL/PLGA electrospun with different alignments and compositions

Zamanlui, S ; Sharif University of Technology | 2018

1028 Viewed
  1. Type of Document: Article
  2. DOI: 10.1080/00914037.2017.1297941
  3. Publisher: Taylor and Francis Inc , 2018
  4. Abstract:
  5. The simultaneous effect of electrospun scaffold alignment and polymer composition on chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBMMSC) is investigated. Aligned and randomly oriented polycaprolactone/poly(lactic-co-glycolic acid) (PLGA) hybrid electrospun scaffolds with two different ratios are fabricated by electrospinning. It is found that aligned nanofibrous scaffolds support higher chondrogenic differentiation of hBMMSCs compared to random ones. The aligned scaffolds show a higher expression level of chondrogenic markers such as type II collagen and aggrecan. It is concluded that the aligned nanofibrous scaffold with higher PLGA ratio could significantly enhance hBMMSC proliferation and differentiation to chondrocytes. © 2018 Taylor & Francis
  6. Keywords:
  7. Cartilage tissue engineering ; Chondrocyte ; Human bone marrow mesenchymal stem cell ; Body fluids ; Bone ; Cell culture ; Cell engineering ; Implants (surgical) ; Nanofibers ; Stem cells ; Tissue engineering ; Chondrocytes ; Chondrogenic differentiation ; Chondrogenic markers ; Electrospun scaffolds ; Human bone marrow mesenchymal stem cells ; Nanofibrous scaffolds ; Simultaneous effects ; Scaffolds (biology)
  8. Source: International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 67, Issue 1 , 2018 , Pages 50-60 ; 00914037 (ISSN)
  9. URL: https://www.tandfonline.com/doi/abs/10.1080/00914037.2017.1297941