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Manufacturing of Magnesium-based Janus Micromotors Capable of Moving in Aqueous Environment and Magnetic Guidance for Biomedical Applications

Paryab, Amir Hosein | 2019

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 51910 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Madaah Hoseini, Hamid Reza
  7. Abstract:
  8. Our goal in this research is to fabricate janus micromotors capable of moving in aquious media and being manipulated by an external magnetic field. Such devices were made via attaching magnetic nanoparticles to the surface of magnesium janus motor. The FTIR study proved their existance and physical attraction to the surface of the motors. They were easily navigated through a static magnetic field and janus motors aligned their motion to the direction of magnetic field. The anisotropic geometry of janus micromotors were verified through scaning electron microscope and elemental analysis. Biocompatibility of magnetised janus motors were examined through mtt assay and it was shown that the bubble propulsion mechanism has no negative effect on the cell viability rate. At the end of the project a type of antibiotic drug were studied to analyze their potentials for drug delivery and bactericidal activity. FTIR study showed their atachment on the surface of gold nanolayer through conjugation. Motors carrying anti bacterial drugs showed higher bactericidal activity compared with the ones not carrying any drugs. They also proved that they can increase the bactericidal activity of the drug itself since they can transport the drug and as a result more surface of the bacteria is touched with antibacterial drug
  9. Keywords:
  10. Spherical Janus Micromotors ; Magnetic Nanodot ; Biocompatibility ; Antibacterial Properties ; Janus Nanoparticles ; Magnetic Guidance

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