Mechanical characterization of the ligaments in subject-specific models of the patellofemoral joint using in vivo laxity tests

Akbar, M ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1016/j.knee.2018.10.001
  3. Publisher: Elsevier B.V , 2019
  4. Abstract:
  5. Background: The purpose of this study was to propose a methodology for mechanical characterization of the ligaments in subject-specific models of the patellofemoral joint (PFJ) of living individuals. Method: PFJ laxity tests were performed on a healthy volunteer using a specially designed loading apparatus under biplane fluoroscopy. A three-dimensional (3D) parametric model of the PFJ was developed in the framework of the rigid body spring model using the geometrical data acquired from the subject's computed tomography and magnetic resonance images. The stiffness and pre-strains of the medial and lateral PFJ ligaments were characterized using a two-step optimization procedure which minimized the deviation between the model predictions and the calibration test results. Sensitivity analyses were performed to investigate the effect of mechanical properties of the non-characterized model components on the characterization procedure and its results. Results: The overall findings indicate that the proposed methodology is applicable and can improve the model predictions effectively. For the subject under study, ligament characterization reduced the root mean square of the deviations between the patellar shift and tilt predicted by the model and obtained experimentally for the validation laxity test (from 6.2 mm to 0.5 mm, and from 8.4° to 1.5°, respectively) and passive knee flexion test (from 1.4 mm to 0.3 mm, and from 2.3° to 1.3°, respectively). The non-characterized mechanical properties were found to have a minimal effect on the characterization procedure and its results. Conclusion: The proposed methodology can help in developing truly patient-specific models of the PFJ, to be used for personalized preplanning of the clinical interventions. © 2018 Elsevier B.V
  6. Keywords:
  7. Biplane fluoroscopy ; Laxity test ; LPFL ; MPFL ; Pshift ; Patellar tilt ; Article ; Calibration ; Computer assisted tomography ; Controlled study ; Fluoroscopy ; Human ; In vivo study ; Knee function ; Ligament ; Nuclear magnetic resonance ; Prediction ; Rigidity ; Sensitivity analysis ; Spring ; Validation process ; Volunteer ; Biological model ; Joint characteristics and functions ; Joint ligament ; Nuclear magnetic resonance imaging ; Pathophysiology ; Physiology ; X-Ray computed tomography ; Adult ; Cadaver ; Humans ; Knee ; Ligaments, articular ; Magnetic resonance imaging ; Male ; Patella ; Patellofemoral joint ; Patient-Specific modeling ; Range of motion, articular ; Tomography, X-Ray computed
  8. Source: Knee ; Volume 26, Issue 6 , 2019 , Pages 1220-1233 ; 09680160 (ISSN)
  9. URL: https://www-sciencedirect-com.ezp2.semantak.com/science/article/pii/S0968016018308858