A multichannel single-well sensor array for rapid and visual discrimination of catecholamine neurotransmitters

Abbasi Moayed, S ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1016/j.snb.2019.126691
  3. Publisher: Elsevier B.V , 2019
  4. Abstract:
  5. In this study, for rapid identification and discrimination of catecholamine neurotransmitters in the presence of ascorbic acid (AA), a tricolor fluorescence probe has been constructed by integrating three recognition elements including blue carbon dots (bCDs), green CdTe quantum dots (gQDs) and red CdTe quantum dots (rQDs) into a single well. The proposed array exhibited ternary fluorescence emissions at 450, 520 and 630 nm with an overall luminescent pink emission under a single wavelength excitation (365 nm). In order to produce distinct response patterns from a single fluorimetric test, the spectral changes and the corresponding color variations of the multichannel fluorescence probe were monitored. Finally, analyzing the response profiles with pattern recognition methods allowed us to identify and discriminate catecholamine neurotransmitters and to also distinguish them from AA which is known as a serious interference in urine samples. Altogether, the developed sensor array can be considered as a rapid and visual tool for diagnostic and therapeutic applications in the near future. © 2019
  6. Keywords:
  7. Catecholamine neurotransmitters ; Naked-eye discrimination ; Sensor array ; Tricolor fluorescence probe ; Cadmium telluride ; Fluorescence ; II-VI semiconductors ; Nanocrystals ; Neurophysiology ; Pattern recognition ; Probes ; Semiconductor quantum dots ; Sensor arrays ; Fluorescence emission ; Fluorescence probes ; Naked-eye ; Pattern recognition method ; Single wavelength excitation ; Therapeutic Application ; Visual discrimination ; Ascorbic acid
  8. Source: Sensors and Actuators, B: Chemical ; Volume 296 , 2019 ; 09254005 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0925400519308913