A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial

Chashmniam, S ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1038/s41430-018-0386-5
  3. Publisher: Nature Publishing Group , 2019
  4. Abstract:
  5. Background/Objectives: Curcumin, a natural polyphenol compound in the spice turmeric, has been found to have potent anti-oxidative and anti-inflammatory activity. Curcumin may treat non-alcoholic fatty liver disease (NAFLD) through its beneficial effects on biomarkers of oxidative stress (OS) and inflammation, which are considered as two feature of this disease. However, the effects of curcumin on NAFLD have been remained poorly understood. This investigation evaluated the effects of administrating curcumin on metabolic status in NAFLD patients. Subjects/Methods: Fifty-eight NAFLD patients participated in a randomized, double-blind, placebo-controlled parallel design of study. The subjects were allocated randomly into two groups, which either received 250 mg phospholipid curcumin or placebo, one capsule per day for a period of 8 weeks. Fasting blood samples were taken from each subject at the start and end of the study period. Subsequently, metabolomics analysis was performed for serum samples using NMR. Results: Compared with the placebo, supplementing phospholipid curcumin resulted in significant decreases in serum including 3- methyl-2-oxovaleric acid, 3-hydroxyisobutyrate, kynurenine, succinate, citrate, α-ketoglutarate, methylamine, trimethylamine, hippurate, indoxyl sulfate, chenodeoxycholic acid, taurocholic acid, and lithocholic acid. This profile of metabolic biomarkers could distinguish effectively NAFLD subjects who were treated with curcumin and placebo groups, achieving value of 0.99 for an area under receiver operating characteristic curve (AUC). Conclusions: Characterizing the serum metabolic profile of the patients with NAFLD at the end of the intervention using NMR-based metabolomics method indicated that the targets of curcumin treatment included some amino acids, TCA cycle, bile acids, and gut microbiota. © 2019, Springer Nature Limited
  6. Keywords:
  7. 2 oxoglutaric acid ; 3 hydroxy 2 methylpropionic acid ; 3 methyl 2 oxovaleric acid ; Chenodeoxycholic acid ; Citric acid ; Curcumin ; Hippuric acid ; Indican ; Kynurenine ; Lithocholic acid ; Methylamine ; Phospholipid ; Succinic acid ; Taurocholic acid ; Trimethylamine ; Unclassified drug ; Valeric acid ; Article ; Blood sampling ; Clinical effectiveness ; Clinical evaluation ; Comparative study ; Controlled study ; Double blind procedure ; Female ; Human ; Intestine flora ; Major clinical study ; Male ; Metabolic fingerprinting ; Metabolomics ; Middle aged ; Nonalcoholic fatty liver ; Nuclear magnetic resonance ; Outcome assessment ; Pilot study ; Randomized controlled trial ; Supplementation ; Treatment duration
  8. Source: European Journal of Clinical Nutrition ; Volume 73, Issue 9 , 2019 , Pages 1224-1235 ; 09543007 (ISSN)
  9. URL: https://pubmed.ncbi.nlm.nih.gov/30647436