Loading...

Synthesis and characterization of magnetic hybrid nanomaterials via RAFT polymerization: A pH sensitive drug delivery system

Pourjavadi, A ; Sharif University of Technology | 2019

992 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.colsurfb.2018.11.006
  3. Publisher: Elsevier B.V , 2019
  4. Abstract:
  5. Herein, a facile and versatile method for the synthesis of a novel magnetic nanocarrier via surface- initiated reversible addition-fragmentation chain transfer (RAFT) polymerization is introduced. At first, RAFT agent was successfully attached to the surface of Fe 3 O 4 nanoparticles and, then, poly (glycidyl methacrylate) (PGMA) chains were grown and anchored onto the surface of Fe 3 O 4 nanoparticles. At the end, hydrazine (Hy) groups were introduced to the PGMA chains via reaction between epoxy rings and hydrazine molecules. Doxorubicin (DOX) was covalently conjugated to the prepared nanocarrier (Fe 3 O 4 @PGMA@Hy) through a hydrazone linkage. The in vitro drug release of Fe 3 O 4 @PGMA@Hy@DOX examined in buffers with pH 7.4 and pH 5.4 exhibited a strong pH-sensitive behavior. The results showed that Fe 3 O 4 @PGMA@Hy@DOX successfully performed the delivery and controlled release of doxorubicin (DOX) anticancer drug. © 2018
  6. Keywords:
  7. Drug delivery ; Magnetic ; Nanocarrier ; PH sensitive ; RAFT polymerization ; Acrylic monomers ; Chains ; Free radical polymerization ; Hydrazine ; Iron oxides ; Living polymerization ; Magnetism ; Magnetite ; Nanoparticles ; PH sensors ; Targeted drug delivery ; Hybrid nanomaterials ; Nanocarriers ; Poly(glycidyl methacrylate) ; RAft polymerization ; Reversible Addition-fragmentation chain transfer polymerization ; Synthesis and characterizations ; Controlled drug delivery ; Magnetic nanoparticle ; Magnetite nanoparticle ; Polymer ; Unclassified drug ; Antineoplastic antibiotic ; Drug carrier ; Nanomaterial ; Antineoplastic activity ; Biocompatibility ; Chemical reaction ; Controlled study ; Cytotoxicity ; Drug delivery system ; Drug release ; Drug stability ; In vitro study ; PH ; Polymerization ; Priority journal ; reversible Addition fragmentation chain transfer polymerization ; Synthesis ; Chemistry ; HeLa cell line ; Human ; Antibiotics, Antineoplastic ; Cell Survival ; Doxorubicin ; Drug Carriers ; Drug Delivery Systems ; Drug Liberation ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Magnetics ; Nanostructures
  8. Source: Colloids and Surfaces B: Biointerfaces ; Volume 174 , 2019 , Pages 153-160 ; 09277765 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0927776518307823