Pulsating Pulmonary Blood Inflow in Total Cavopulmonary Connection (TCPC) after Fontan Surgery

Moradi, Hamed | 2020

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 53087 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Sayadi, Hassan; Firoozabadi, Bahar; Navabi Shirazi, Mohammad Ali; Malakan Rad, Elaheh
  7. Abstract:
  8. Patients with a single ventricle disease who have undergone Fontan surgery have always had long-term complications. These complications include pulmonary artery stiffness and decreased ability to exercise. In fact, due to removal of the right ventricle from the circulatory system, blood pressure and pulsatility inflow to total cavopulmonary connection (TCPC) are reduced following this surgery. Creating waves (radial displacement) on the IVC (Inferior Vena Cava) wall can increase pulmonary flow pulsations. The Objective of this study is to test the effect of induced wave amplitude on the pulmonary flow pulsations at the rest condition. Computational fluid dynamic (CFD) simulations were performed on the patient-specific model of a 10-year-old girl. 3D geometry was obtained from CT- angiography series images of the patient. Also, IVC and SVC (Superior Vena Cava) flows were acquired from the echocardiography. A range of induced wave amplitude were simulated to calculate the pulsatility index and pressure gain. The wall shear stresses and pressure distribution were also examined. Pulsatility index up to 0.98 and 0.81 were achieved for RPA (Right Pulmonary Artery) and LPA (Left Pulmonary Artery), respectively. Pressure gains and energy loss increased with the amplitude of induced wave. Creating waves on IVC increase pulsatility and pressure gain in TCPC, which shows that this method can be further developed as an effective method for some patients with a failing extracardiac Fontan
  9. Keywords:
  10. Fluid-Structure Interaction ; Pulsating ; Total Cavopulmonary Connect (TCPC) ; Fontan Operation ; Pulmonary Cardiovascular System ; Blood Flow

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