Design and application of (Fe3O4)-GOTfOH based AgNPs doped starch/PEG-poly (acrylic acid) nanocomposite as the magnetic nanocatalyst and the wound dress

Forouzandehdel, S ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1016/j.molstruc.2020.128142
  3. Publisher: Elsevier B.V , 2020
  4. Abstract:
  5. As a novel, recyclable nanocatalyst, (Fe3O4)-GOTfOH based Ag nanoparticles doped Starch/PEG-poly (acrylic acid) nanocomposite (Fe3O4@GOTfOH/Ag/St-PEG-AcA) was applied for one-pot synthesis of 2,4,6-triarylpyridine derivatives under water solvent conditions. The prepared nanocomposite was also evaluated in terms of biocompatibility for wound healing. Fe3O4@GOTfOH/Ag/St-PEG-AcA could be easily removed from the mixture of the reaction by an external magnet and recycled without a considerable decrease of activity even after 10 runs. The new nanocatalyst offered better efficiencies than other commercially available sulfonic acid catalysts. In terms of the bioactivity of nanocatalyst, good antimicrobial efficiency was confirmed on E. coli bacteria. Besides, histology of repaired wounds in Fe3O4@GOTfOH/Ag/St-PEG-AcA for a healed group of mice showed better fibroblast distribution and more compact collagen fiber organization compared to wounds in the control group. © 2020 Elsevier B.V
  6. Keywords:
  7. 2,4,6-Triarylpyridines ; Hydrogels ; Biocompatibility ; Carboxylic acids ; Cell culture ; Efficiency ; Escherichia coli ; Magnetite ; Mammals ; Nanocatalysts ; Nanocomposites ; Silver nanoparticles ; Starch ; Synthesis (chemical) ; Ag nanoparticle ; Collagen fiber ; Control groups ; Design and application ; Magnetic nanocatalyst ; Nano-catalyst ; One-pot synthesis ; Wound healing ; Iron oxides
  8. Source: Journal of Molecular Structure ; Volume 1214 , 2020
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0022286020304671