Scaling behavior in measured keystroke time series from patients with Parkinson’s disease

Madanchi, A ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1140/epjb/e2020-100561-4
  3. Publisher: Springer , 2020
  4. Abstract:
  5. Abstract: Parkinson has remained as one of the most difficult diseases to diagnose, as there are no biomarkers to be measured, and this requires one patient to do neurological and physical examinations. As Parkinson is a progressive disease, accurate detection of its symptoms is a crucial factor for therapeutic reasons. In this study, we perform Multifractal Detrended Fluctuation Analysis (MFDFA) on measured keystroke time series for three different categories of subjects: healthy, early-PD, and De-Novo patients. We have observed different scaling behavior in terms of multifractality of the measured time series, which can be used as a practical tool for diagnosis purposes. Additionally, the source of the multifractality has been studied which shows that in healthy and early-PD subjects, multifractality due to the long-range correlations is stronger than the influence of its probability distribution function (PDF) fatness, while in De-Novo patients, both shape of PDF and long-range correlations are contributing to observed multifractality. Graphical abstract: [Figure not available: see fulltext.]. © 2020, EDP Sciences / Società Italiana di Fisica / Springer-Verlag GmbH Germany, part of Springer Nature
  6. Keywords:
  7. Statistical and Nonlinear Physics ; Diagnosis ; Distribution functions ; Fractals ; Time series ; Long range correlations ; Multifractal detrended fluctuation analysis ; Multifractality ; Progressive disease ; Scaling behavior ; Time series analysis
  8. Source: European Physical Journal B ; Volume 93, Issue 7 , July , 2020
  9. URL: https://link.springer.com/article/10.1140/epjb/e2020-100561-4#article-info