Evaluation of endothelial response to reactive hyperaemia in peripheral arteries using a physiological model

Parsafar, M. H ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. Publisher: Inderscience Publishers , 2020
  3. Abstract:
  4. Non-invasive measurement of flow-mediated dilation (FMD) in the brachial artery for assessing endothelial function is costly and operator-dependent, limiting its application to research cases. In this paper, an approach based on a physiological model between normalized central blood pressure and finger photoplethysmogram is presented. Baseline model parameters are estimated using a genetic algorithm in 30 subjects consisting of ten normal blood pressure (BP), ten high-BP and ten elderly volunteers. Beat-to-beat fitness values after reactive hyperaemia are calculated using baseline (before cuff occlusion) data. Results show that stimulus-induced changes are fairly described with a first order dynamic. The time constant of this first order system is significantly larger for normal BP compared to high BP (p-value = 0.004) and elderly subjects (p-value = 0.01). Our findings hint to the potential of the proposed physiological, model-based approach for evaluating cardiovascular health using FMD. © 2020 Inderscience Enterprises Ltd
  5. Keywords:
  6. Cardiovascular modelling ; Flow-mediated dilation ; FMD ; Photoplethysmography ; Tube-load model ; Viscoelasticity ; Blood ; Blood pressure ; Genetic algorithms ; Endothelial function ; First order systems ; Flow mediated dilation ; ITS applications ; Model based approach ; Non- invasive measurements ; Peripheral arteries ; Photo-plethysmogram ; Physiological models
  7. Source: International Journal of Biomedical Engineering and Technology ; Volume 33, Issue 4 , 2020 , Pages 305-324
  8. URL: https://www.inderscience.com/info/inarticle.php?artid=108989