Graphene oxide functionalized with oxygen-rich polymers as a pH-sensitive carrier for co-delivery of hydrophobic and hydrophilic drugs

Pourjavadi, A ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jddst.2020.101542
  3. Publisher: Editions de Sante , 2020
  4. Abstract:
  5. In this work, a novel carrier based-on modified graphene oxide was designed for co-delivery of hydrophobic and hydrophilic anticancer drugs (curcumin (Cur) and doxorubicin (DOX) as the model of drugs). The hydroxyl groups at the edges of graphene oxide (GO) sheets were used as the initiation sites for growing poly(epichlorohydrin) (PCH) chains. Then, hyperbranched polyglycerol (HPG) was grafted on the hydroxyl end groups of PCH (PCH-g-HPG). Pendant chlorines in the main chain of GO-PCH-g-HPG were replaced with hydrazine. The modification of GO sheets with oxygen-rich polymers increased water solubility of graphene oxide. Doxorubicin was loaded onto the nanocarrier by covalent bonding with hydrazine pendant group and curcumin was loaded through π−π stacking with graphene oxide sheets which were partially reduced to graphene sheets during the carrier preparation. The MTT assay revealed that the carrier had low toxicity because of the presence of oxygen-rich polymers. The drug release of the carrier was investigated and a pH-sensitive behavior was observed for the release of drugs from the carrier. The cellular uptake images proved that co-encapsulation of both DOX and Cur drugs showed higher drug internalization in comparison with the single drug loaded carrier. According to the results, a combination of both drugs exhibited a synergistic behavior for chemotherapy. © 2020
  6. Keywords:
  7. Co-delivery ; Graphene oxide ; Hyperbranched polyglycerol ; pH-sensitive ; Poly(epichlorohydrin) ; Chlorine derivative ; Curcumin ; Doxorubicin ; Hydrazine ; Hydroxyl group ; Nanocarrier ; Nanosheet ; poly(epichlorohydrin) graft hyperbranched polyglycerol ; Polymer ; Unclassified drug ; Cancer chemotherapy ; Comparative study ; Controlled study ; Covalent bond ; Drug cytotoxicity ; Drug delivery system ; Drug efficacy ; Drug release ; Drug solubility ; Human cell ; Hydrophilicity ; Hydrophobicity ; Internalization ; MCF-7 cell line ; MTT assay ; Nanoencapsulation ; Nanopharmaceutics ; PH ; Reduction (chemistry) ; Synergistic effect
  8. Source: Journal of Drug Delivery Science and Technology ; Volume 56 , 2020
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S1773224719314029