CaTiO3/α-TCP coatings on CP-Ti prepared via electrospinning and pulsed laser treatment for in-vitro bone tissue engineering

Yadi, M ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1016/j.surfcoat.2020.126256
  3. Publisher: Elsevier B.V , 2020
  4. Abstract:
  5. In this study, the in-vitro bone regeneration ability of commercial pure titanium (CP-Ti) surface modified via electrospun polyvinylidene/hydroxyapatite (PVP/HA) masking and subsequent Nd-YAG pulsed laser treatment was investigated. The ratio of HA to PVP played a significant role in achieving a perfect homogenous mask on the CP-Ti. In the laser treatment process, the parameter of area scanning speed (ASS) had an important influence on the final surface morphology. A favorable range was defined for this parameter where these two conditions were satisfied: no PVP remaining and no severe substrate melting. Within a favorable range of ASS, as decreasing ASS exchanged the surface structure from detached particles to a pattern-like network. The calcium titanate CaTiO3 (CTO) and α-tricalcium phosphate (α-TCP) were formed as the main components on the CP-Ti surface. The coating had an adequate adhesion to the CP-Ti surface. Furthermore, a surface with a water affinity between hydrophilic and hydrophobic was obtained. The in-vitro bioactivity test revealed that the surface modification enhanced the bone-like apatite formation. The cytocompatibility assays confirmed that the cell attachment and spreading of the osteosarcoma-like cells (MG63) were improved by the surface treatment. The development of surface modification techniques opens new avenues in bone tissue engineering applications. © 2020 Elsevier B.V
  6. Keywords:
  7. Bone regeneration ; CaTiO3 ; CP-Ti ; Electrospinning ; Laser modification ; Bone ; Coatings ; Morphology ; Perovskite ; Phosphate minerals ; Pulsed lasers ; Surface morphology ; Tissue ; Tissue regeneration ; Titanium metallography ; Yttrium aluminum garnet ; Bone tissue engineering ; Bone-like apatite formations ; Commercial pure titanium ; Hydrophilic and hydrophobic ; In-vitro bioactivity ; Nd-YAG pulsed lasers ; Surface modification techniques ; Tri-calcium phosphates ; Surface treatment
  8. Source: Surface and Coatings Technology ; Volume 401 , 2020
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0257897220309257