Core-sheath gelatin based electrospun nanofibers for dual delivery release of biomolecules and therapeutics

Zandi, N ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1016/j.msec.2019.110432
  3. Publisher: Elsevier Ltd , 2020
  4. Abstract:
  5. Coaxial electrospinning with the ability to use simultaneously two separate solvents provides a promising strategy for drug delivery. Nevertheless, controlled release of hydrophilic and sensitive therapeutics from slow biodegradable polymers is still challenging. To address this gap, we fabricated core-sheath fibers for dual delivery of lysozyme, as a model protein, and phenytoin sodium as a small therapeutic molecule. The sheath was processed by a gelatin solution while the core fibers were fabricated from an aqueous gelatin/PVA solution. Microstructural studies by transmission and scanning electron microscopy reveal the formation of homogeneous core-sheath nanofibers with an outer and inner diameter of 180 ± 48 nm and 106 ± 30 nm, respectively. Thermal gravimetric analysis determines that the mass loss of the core-sheath fibers fall between the mass loss values of individual sheath and core fibers. Swelling studies indicate higher water absorption of the core-sheath mat compared to the separate sheath and core membranes. In vitro drug release studies in Phosphate Buffered Saline (PBS) determine sustained release of the therapeutics from the core-sheath structure. The release trails three stages including non-Fickian diffusion at the early stage followed by the Fickian diffusion mechanism. The present study shows a useful approach to design core-sheath nanofibrous membranes with controlled and programmable drug release profiles. © 2019 Elsevier B.V
  6. Keywords:
  7. Biodegradable polymer ; Core-sheath ; Dual drug release ; Fibrous membrane ; Nanocarrier ; Protein ; Biodegradable polymers ; Diffusion in solids ; Drug products ; Fibers ; Fibrous membranes ; Functional polymers ; Gravimetric analysis ; Nanofibers ; Proteins ; Scanning electron microscopy ; Targeted drug delivery ; Thermogravimetric analysis ; Water absorption ; Coaxial electrospinning ; Core sheaths ; Core-sheath structures ; Drug release ; Fickian diffusion mechanism ; Nanocarriers ; Phosphate-buffered salines ; Thermal gravimetric analysis ; Controlled drug delivery ; Gelatin ; Lysozyme ; Nanofiber ; Phenytoin ; Animal ; Cell line ; Chemistry ; Delayed release formulation ; Mouse ; Pharmacokinetics ; Pharmacology ; Animals ; Cell Line ; Delayed-Action Preparations ; Gelatin ; Mice ; Muramidase ; Polyvinyl Alcohol
  8. Source: Materials Science and Engineering C ; Volume 108 , 2020
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0928493119330310